Protein aggregation determinants from a simplified model: Cooperative folders resist aggregation
نویسندگان
چکیده
منابع مشابه
Protein aggregation determinants from a simplified model: cooperative folders resist aggregation.
Two-chain aggregation simulations using minimalist models of proteins G, L, and mutants were used to investigate the fundamentals of protein aggregation. Mutations were selected to break up repeats of hydrophobic beads in the sequence while maintaining native topology and folding ability. Data are collected under conditions in which all chain types have similar folded populations and after equi...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2005
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.041017305